Improving Solubility of Ambrisentan via Electrospinning
(0) Drug-loaded nanofibres have been successfully prepared by an electrospinning technique, using ambrisentan, polyvinylpyrrolidone K60 (PVP K60) and the mixed solvent consisting of methanol and dimethylacetamide (DMAC) as the starting materials. The structures of the electrospun drug-loaded nanofibers were characterized by SEM and FTIR. The results indicated that the products were the threedimensional continuous web structure nanofibres with 300～600 nm in average outer-diameter. The state of ambrisentan in the nanofibres was also discussed. In vitro wetting and dissolution tests showed that the drug-loaded nanofiber membranes were able to absorb water and dissolve on the water surface in 60 s through the polymer-controlled mechanism. The drugloaded nanofibers obviously improved ambrisentans solubility.
electrospinning nanofibers ambrisentan poorly water-soluble drug polyvinylpyrrolidone
XIE Jian-gang WU Cheng-yao QUAN Jing YU Deng-guang ZHU Li-min
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P. R. Ch College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P. R. Ch
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
152-156
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）