Fabrication and Characterization of Silk Fibroin/hyaluronic Acid Nanofibrous Scaffolds
The native extracellular matrix (ECM) is composed of a cross-linked porous network of multifibril collagens and glycosaminoglycans. Nanofibrous scaffolds of silk fibroin (SF) and hyaluronic acid (HA)blends were fabricated using water as a solvent to biomimic the native ECM via electrospinning. The morphology of the electrospun scaffolds was investigated with SEM. The SEM images indicated that electrospun SF/HA fibers were ribbon-shaped and the average width obviously decreased with increasing HA content, but no fibers were observed when the volume ratio of SF/HA was less than 5 ∶ 5. The surface tensions of SF/HA mixed solutions gradually decreased along with HA increase at the beginning, and then gradually increased when the volume ratio of SF/HA reached 5 ∶ 5. After treated with 75％ ethanol vapor for 24 h, the fibers still remained good morphologies and water-resistance. Meanwhile, FTIR demonstrated conformation of SF transformed from random coil or αhelix to β-sheet structure. Electrospun SF/HA nanofibers may provide an ideal tissue engineering scaffolds.
electrospinning silk fibroin hyaluronic acid nanofibrous scaffolds
ZHANG Kui-hua FAN Lin-peng CAI Zeng-xiao YIN An-lin MO Xiu-mei
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Biomaterials end Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biologica
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
175-179
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）