A Thermoresponsive Topography Substrate for Cell Adhesion, Growth and Thermally Induced Detachment
Substrate topography is one of the key factors that influence cell behavior. A thermoresponsive topography substrate for cell culture was designed and prepared by UV-induced graft-polymerization of N-isopropylacrylamide (NIPAAm) on polystyrene (PS) film with topography structure. The topography of the modified PS films was observed by scanning electron microscope (SEM). X-ray photoelectron spectroscopy (XPS) analysis revealed that poly(Nisopropylacrylamide) (PNIPAAm) were successfully photografted onto topography surfaces of PS films. Mouse fibroblast (L929) cells cultured on thermoresponsive topography substrate exhibited rapid cell adhesion, growth and thermally induced detachment.
thermoresponsive topography N-isopropylacrylamide(NIPAAm)
NIE Ping-ping HE Xiao-ling CHEN Li
Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tionjin 300160, P. R. China School of Environment and Chemical Engineering, Tianjin Polytechnic University, Tia
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
215-219
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）