Acetylation of Dendrimer-Entrapped Gold Nanoparticles: Synthesis, Stability, and X-Ray Attenuation Property
Functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) are of scientific and technological interest in biomedical applications. In this work, Au DENPs prepared using amine-terminated generation 5 poly (amidoamine) dendrimers as templates were subjected to acetylation in order to neutralize the positive surface charge of the particles. By varying the molar ratio of gold salt/G5 dendrimer, the acetylated Au DENPs with a size range of 2～4 nm can be prepared. Meanwhile, glucose was added to the dialysis liquid of the acetylated Au DENPs to avoid possible particle aggregation after lyophilization. The acetylated Au DENPs with different compositions (Au salt/dendrimer molar ratios) were characterized using 1H NMR, transmission electron microscopy, and UV-vis spectrometry. We show that when the molar ratio of Au salt/dendrimer is equal or larger than 75, the acetylated Au DENPs have a slight aggregation after lyophilization, and the addition of glucose is able to preserve the colloidal stability of the particles. X-ray absorption measurements show that the attenuation of the acetylated Au DENPs is much higher than that of the iodine-based contrast agent at the same molar concentration of the active element (Au versus iodine). These findings suggest a great potential of using Au DENPs as a promising contrast agents for CT imaging applications.
dendrimers gold nanoparticles acetylation stability X-ray attenuation
PENG Chen WANG Han GUO Rui SHEN Ming-wu CAO Xue-yan ZHANG Gui-xiang SHI Xiang-yang
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P Department of Radiology, Affilioted Shanghai First Peoples Hospital, Medical College, Shanghai Jiao
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
220-224
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）