Adhesion and Proliferation of Fibroblasts onto Electrospun Halloysite/Poly(lactic-co-glycolic acid) Composite Nanofibers

摘要：

Our earlier study shows that electrospun halloysite/poly( lactic-co-glycolic acid) (PLGA) nanofibers display enhanced mechanical property and render effective drug encapsulation and sustained release. The aim of this study is to investigate the influence of the incorporation of halloysite nanotubes (HNTs) within PLGA nanofibers on their in vitro biocompatibility. The adhesion and proliferation of rat fibroblast cells cultured on both PLGA and halloysite/PLGA fibrous scaffolds were compared through 3-(4,5-dimethylthiazol-2-yl)-2, 5diphenyl tetrazolium bromide (MTT) assay of cell viability. The morphology of cells was observed using scanning electron microscopy (SEM). We show that electrospun PLGA and HNTs/ PLGA nanofibers are able to promote cell attachment and proliferation, suggesting that the incorporation of HNTs within PLGA nanofibers does not compromise the biocompatibility of the PLGA nanofibers. Given the enhanced mechanical properties of HNTs/PLGA nanofibers for drug encapsulation and sustained release, we expect that the electrospun HNTs/ PLGA composite nancfibrous scaffold should be amenable for applications in tissue engineering and pharmaceutical sciences.

关键词： halloysite poly(lactic-co-glycolic acid) cell culture biocompatibility

作者: QI Rui-ling CAO Xue-yan SHEN Ming-wu YU Jian-yong SHI Xiang-yang

作者单位: Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai

会议类型: 国际会议

会议名称: 2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)

会议地点: 上海

会议语种:英文

页码: 225-229

在线出版日期: 2010-05-28（万方平台首次上网日期，不代表论文的发表时间）