Preparation and Characterization of Silk Fibrion and Chitosan Blend Nanofibers by Electrospinning
In the present study, Silk fibroin(SF)/chitosan(CS) were fabricated by electrospunning. The diameter of SF/CS blend nanofibers decreased gradually from 484 to 105 nm with the increase of CS content. The conformatJon change was investigated by means of Fourier Transform Infrared (FTIR) spectra and X-Ray diffraction. The SF/CS nanofibers showed characteristic adsorption peaks of the random coil structure of SF, and the addition of CS did not induce SF conformation change from α-helix to β-sheet. With the treatment of glutaraldehyde(GTA) vapor, the SF conformated from α-helix to βsheet, and the stability of SF/CS membranes were significantly enhanced. The electrospining SF/CS blend nanofibers are designed to mimic the native extracellular matrix and can be used as tissue engineering scaffolds.
silk fibrion chitosan electrospinning nanofibers biomaterials
CAI Zeng-xiao ZHANG Kui-hua FAN Lin-peng WANG Hong-sheng HE Chuang-long MO Xiu-mei
Biomaterials and Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biologica Biomaterials and Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biologica Biomaterials and Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biologica
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
245-249
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）