Fabrication Tissue Engineering Heart Valve Leaflet Scaffold Using Complex Electrospinning Method
(0) Collagen functionalized thermoplastic polyurethane nanofibers (TPU/collagen) were successfully produced by coaxial electrospinning technique with a goal to develop biomedical tissue engineering heart valve leaflet scaffold. A series of tests were conducted to characterize the compound nanofiber and its membrane in this study. Surface morphology and interior structure of the ultrafine fibers were characterized by scanning electron microscopy and transmission electron microscopy, whereas the fiber diameter distribution was also measured. Porosities of different kinds of electrospun mats were determined. The surface chemistry and chemical composition of collagen/TPU coaxial nanofibrous membranes were verified by X-ray photoelectron spectroscopy and Fourier transform infrared spectrometry. Mechanical measurements were carried out by applying tensile test loads to samples which were prepared from electrospun ultra fine nonwoven fiber mats. The results demonstrated that coaxialelectrospun composite nanofibers has the characters of native extracellular matrix and may be used effectively as an alternative material for tissue engineering heart valve leaflet scaffold and functional biomaterials.
complex electrospinning collagen/thermoplastic polyurethane surface modification composite nanofiber
CHEN Rui HUANG Chen MORSI Yos MO Xiu-mei KE Qin-fei
College of textiles, Donghua University, Shanghai, 201620, China Faculty of engineering and industry science, Swinburne Unibersity of Technology, Melbourne, Victori College of chemistry and chemical engineering and biological engineering, Donghua University, Shangh
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
261-266
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）