Multi-drug Loaded and Released from Electrospun Nanofibrous Scaffolds
This study is aim at developing a novel type of tissue engineering scaffold or drugs delivery carrier with the capability of encapsulation and controlled release of multi-drug. In this study, Rhodamine B and Bovine Serum Albumin (BSA) were successfully incorporated into nanofibers by emulsion electrospinning. The morphology of composite nanofibers was studied by Scanning Electron Microscopy (SEM). In vitro drugs release behaviors from composite nanofibrous mats were investigated. From the drug release profiles, it shows that where the drug or protein is put into oil solvent or water can affect the drug release profile in the electrospun fibers. The results imply that that the drug and/or protein release profile in composite fibrous mats made from electrospinning can be controlled by altering the emulsion electrospinning process and has significant implications for a wide range of applications.
emulsion electrospinning multi-drug nanofibers controlled release
SU Yan MO Xiu-mei
Biomaterials and Tissue Engineering Laboratory, College of Chemistry & Chemical Engineering and Biotechnology,Donghua University, Shanghai, 201620 (China)
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
313-315
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）