Synchronous Electrospun Hybrid Ultrafine Fibers from Polyacrylic Resin Ⅱ and Ⅳ

摘要：

Hybrid drug-loaded ultrafine fibers were successfully prepared of polyacrylic resin Ⅱ and Ⅳ using a dualsyringe programmable infusion pump. Drug-loaded fibers electrospun from co-dissolving solutions of polyacrylic resin Ⅱ ultrafibers were prepared for comparision. The hybrid fibers showed pH-sensitive dissolution properties, one portion of the hybrid was dissolved in low pH circumstance, and the other portion of the hybrid was dissolved above pH6.8. The morphology of the hybrid fibers were observed using scanning electron microscopy (SEM), the results showed that all the ultrafine fibers had a uniform structure and smooth surface. The in vitro dissolution tests showed that drug release from the hybrid fibers sustained for almost 8 hours. The results indicated that the hybrid drug-loaded ultrafibers released the active pharmaceutical ingredients in stomach and intestine stage by stage, respectively. And electrospun fibers improved the dissolution profiles of poorly water-soluble drugs. This kind of the hybrid fibers may find applications in designing and preparing novel targeted DDS (drug delivery systems), sustained-release DDS and multi-drugs controlled release DDS.

关键词： hybrid ultrafine fibers polyacrylic resin synchronous electrospinning pH-sensitive

作者: SHEN Xia-xia YU Deng-guang BRANFORD-WHITE Christopher ZHU Li-min

作者单位: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P Institute for Health Research and Policy, London Metropolitan University, London N7 8DB, UK College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P

会议类型: 国际会议

会议名称: 2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)

会议地点: 上海

会议语种:英文

页码: 362-366

在线出版日期: 2010-05-28（万方平台首次上网日期，不代表论文的发表时间）