In vivo biocompatibility studies of nano TiO2 materials
TiO2 nanomaterials with different dimensions(zero and one), sizes(20nm, 50nm and 100nm in diameter) and crystal structures(100％ rutile, 100％ anatase and combination of 20％ rutile and 80％ anatase) were confected to suspensions and ointment with varied concentrations and evaluated in animal model (Balb-c mouse). These mouse were divided into various groups randomly, with suspension intraperitoneally injected or ointment transdermally daubed. Heart, lung, liver and kidney were collected and prepared to HE sample after one week. Spectrophotometry was applied to study total antioxide capability and catalase activity of blood and tissues. It has been shown that all TiO2 nanomaterial groups had no effect on lives’ morphology and oxidative stress, with no obvious histopathological changes observed in heart, lung, liver and kidney, and these tissues presented no vacuolar degeneration, necrosis edema, engorgement and inflammation.
TiO2 nanomaterials in vivo biocompatibility morphology oxidative stress level
Wei Han Yuedan Wang Yufeng Zheng
State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nano Department of Immunology, School of Basic Medicine, Peking University, Beijing 100083, China
国际会议
青岛
英文
389-392
2009-10-09（万方平台首次上网日期，不代表论文的发表时间）