Simulation of dewetting process on micropillar array
DNA molecules can be stretched and immobilized onto a solid surface containing surface microstructures, to form a well-defined array by dewetting the surface with DNA solution. However, the mechanism of DNA stretching, immobilizing and patterning in this molecular combing process is not well understood, especially for micropillar-patterned surface. In this preliminary study, we demonstrated the generation of stretched DNA nanostrand arrays and morphologies on micropillar patterned surface, where this dewetting process is also simulated based on a deforming bodyfitted grid approach. The dewetting dynamics provide insights for explaining the stretching, immobilizing and patterning of DNA molecules on micropillars obtained from corresponding experiments.
Dewetting process Micropillar array Numerical simulation
S W Chau C H Lin J Guan L J Lee
Dept. of Mech. Eng., National Taiwan University of Sci. and Tech., Taipei, China Dept. of Mech. Eng., Chung Yuan University, Jhongli, China Dept. of Chemical and Biomolecular Engineering, Florida State University, Tallahassee, FL, USA Dept. of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA
国际会议
杭州
英文
1000-1003
2009-04-08（万方平台首次上网日期，不代表论文的发表时间）