Imaging hypoxic injury sites using live bacteria

摘要：

Certain strains of bacteria, such as E. coli, Salmonella, and Clostridium, selectively colonize and grow in tumors. We have demonstrated that E. coli and Salmonella spp are capable of targeting both primary tumors and metastases, a feature that has been exploited for tumor-selective drug delivery as well detection. To facilitate the monitoring of these strains in vivo, bacteria have been engineered to express bioluminescence or fluorescence reporter genes, which enabled investigators to track migration patterns and determine the fate of the bacteria in a manner that is simple, non-invasive and amenable to repeated observations.

作者: Hyon E. Choy Jung-Joon Min

作者单位: Department of Microbiology, Chonnam National University Medical School, 5, Hak 1 dong, Dong-gu, Gwan Department of Nuclear Medicine, Chonnam National University Medical School, 5, Hak 1 dong, Dong-gu,

会议类型: 国际会议

会议名称: ACP2009亚太光纤通信与光电国际会议

会议地点: 上海

会议语种:英文

页码: 1-1

在线出版日期: 2009-11-01（万方平台首次上网日期，不代表论文的发表时间）