A POSSIBLE MECHANISM FOR THE DECREASE IN SERUM THYROXINE LEVEL BY TCDD-LIKE PCB, 3,3,4,4,5-PENTACHLOROBIPHENYL IN MICE

摘要：

Introduction Most polychlorinated biphenyl (PCB) congeners, such as 2,3,4,4,5-pentachlorobiphenyl, 3,3,4,4,5-pentachlorobiphenyl (CB126), and 2,2,4,4,5,5- and 2,3,3,4,4,5-hexachlorobiphenyls, are known to decrease the levels of serum thyroid hormone and to increase the activities of hepatic drug-metabolizing enzymes in rats and mice. As possible mechanisms for the PCB-mediated decrease in level of serum thyroid hormone, induction of hepatic UDP-glucuronosyltransferases (UDP-GTs), especially UGT1As, responsible for thyroid hormone metabolism and competitive inhibition on the formation of thyroid hormone-TTR complex are considered.

作者: Yoshihisa Kato Koichi Haraguchi Makiko Kubota Shin-ichi Ikushiro Toshiyuki Sakaki Nobuyuki Koga Shizuo Yamada Masakuni Degawa

作者单位: Kagawa School of Pharmaceutical Sciences,Tokushima Bunri University,Sanuki,Kagawa 769-2193,Japan Daiichi College of Pharmaceutical Sciences,Fukuoka 815-8511,Japan School of Pharmaceutical Sciences and Global Center of Excellence (COE) Program in the 21st Century, Faculty of Engineering,Toyama Prefectural University,Toyama 939-0398,Japan Faculty of Nutritional Sciences,Nakamura Gakuen University,Fukuoka 814-0198,Japan

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）