DEBROMINATED AND HYDROXYLATED METABOLITES OF INDIVIDUAL POLYBROMINATED DIPHENYL ETHERS (PBDEs) IN JUVENILE COMMON SOLE (SOLEA SOLEA)
The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea) exposed to spiked contaminated food during three months followed by a five-month depuration period. Fish contamination by individual PBDEs was followed in muscle and liver, while methoxylated (MeO-) and hydroxylated (HO-) PBDEs were determined in plasma. Several PBDE congeners that were not present in the spiked food, nor in control fish, were identified in the tissues of fish fed contaminated food, revealing transformation of PBDEs; mainly via debromination. The main debrominated congeners were BDE-49, BDE-154, and a penta-BDE tentatively identified as BDE-119 and reported here for the first time. MeO- and HO- congeners were also identified in fish plasma. While all MeOand also some HO- congeners probably originate from natural sources, two HO- congeners, i.e. 4-OH-BDE-49 and 4-OH-BDE-101, were thought to derive from metabolism. 4-OH-BDE-49 has been previously reported as BDE-47 metabolite. 4-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. The results show that PBDEs undergo metabolisation in juvenile soles, either via debromination and formation of HO- metabolites.
Munschy C. Héas-Moisan K. Tixier C. Buchet V. Le Bayon N.
Institut Francais de Recherche pour lExploitation de la Mer (IFREMER),Laboratory of Biogeochemistry Institut Francais de Recherche pour lExploitation de la Mer (IFREMER),Laboratory of Adaptation,Repr
国际会议
北京
英文
1-4
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）