Determination of Perfluorooctane Sulfonates (PFOS) in the Coating of Nonstick Cooker by HPLC/MS/MS
A novel and rapid method based on high performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) with accelerated solvent extraction (ASE) was developed for quantitative detection of trace perfluorooctane sulfonates (PFOS) in the coating of nonstick cooker. PFOS residue was extracted from the coating of nonstick cooker by acetonitrile with ASE. The extract was filtrated through membrane with 0.2 μm diameter. The filtration liquid was injected into HPLC and determined using acetonitrile and 10 mmol/L ammonium acetate solution with the volume ratio of 4:1 as mobile phase. PFOS was detected using electrospray ionization (ESI) on a tandem mass spectrometer in multiple reaction monitoring mode. Qualitative analysis of PFOS could be performed using the retention time of the mass chromatogram and the relative abundance of two daughter ions of PFOS, and quantitative analysis was conducted using external standard method. The linear calibration curve was obtained in the range of 0.002 - 0.1 μg/mL with a linear correlation coefficient (R2) of 0.999. The recovery for PFOS was 95.63 - 101.75％ with relative standard deviation of 1.57 - 3.59％. And the detection limit for PFOS was 0.4 μg/m2 with the signal-to-noise ratio of 10, which would meet the restriction requirement for PFOS content in nonstick cooker in the EU directives. With high accuracy and sensitivity, the sample treatment is simple and rapid, and the method could be used for PFOS inspection in the coating of nonstick cooker.
High performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) perfluorooctane sulfonates (PFOS) coating nonstick cooker accelerated solvent extraction (ASE)
CHEN Hui-ming CHENG Yan CHEN Wei LI Xiao-juan Chen Dong-dong YU Wen-lian LI Shu-juan
Research Center for Import-Export Chemicals Safety of General Administration of Quality Supervision,Inspection and Quarantine of the Peoples Republic of China (AQSIQ),Chinese Academy of Inspection and Quarantine,Beijing 100123,China
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）