Joint Effects of Phthalate Exposure and Serum Paraoxonase (PON1) Activity on Estrogen-dependent Diseases in Taiwanese Women
This study was to examine whether the estrogen-dependent diseases are associated with phthalate exposure and how serum PON1, an anti-oxidant protein, may modulate the disease risk. We conducted a case-control study where Group 1 were patients of either endometriosis or adenomyosis (n = 41), Group 2 were patients of leiomyoma (n = 31) and Group 3 were disease-free controls (n = 70). Patients of Group 1 and 2 had significantly lower serum PON1 activity as compared to controls after adjustment for age and second-hand smoking. No significant differences in phthalate metabolites were found between cases and controls. However, we noticed a joint effect on disease risk between serum PON1 activity and phthalates exposure. For those of low serum PON1 activity and high level of mono-2-ethylhexyl phthalate (MEHP), their risk for leiomyoma was significantly increased (OR = 11.9, p < 0.05). A similar joint effect was also found for Group 1 patients. The significant interaction between PON1 and phthalates indicates that oxidative stress may play an important role in the pathophysiology of the diseases.
Meng-Chu Chung Shu-Li Wang Eng-Mei Tsai Ya-Hui Wang Wan-Fen Li
Division of Environmental Health and Occupational Medicine,National Health Research Institutes,Zhuna Division of Environmental Health and Occupational Medicine,National Health Research Institutes,Zhuna Department of Obstetrics and Gynecology,Kaohsiung Medical University Hospital,Kaohsiung
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）