IDENTIFICATION OF HUMAN METABOLITES OF 2,3,7,8-TCDD
For the first time, two polar metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were identified in various tissues of a human suffering from severe TCDD intoxication. 2,3,7-trichloro-8-hydroxydibenzo-p-dioxin and 1,3,7,8-tetrachloro-2-hydroxy-dibenzo-p-dioxin were identified in serum, faeces, and urine by gas chromatography high resolution mass spectrometry. Highest amounts of these metabolites were detected in faeces whereas serum and urine contained only traces. The relative amount of TCDD metabolites excreted via faeces accounts to approximately 50％ of the totally eliminated TCDD by this route. As only small amounts of TCDD metabolites were detected in urine, renal excretion of these compounds can be considered as minor elimination pathway. In serum the relative amount of metabolites was 50 times lower than in faeces, probably due to the rapid elimination of the metabolites after formation in the liver by phase I and II enzymes and transferred via the bile to the intestine.
Zennegg M Sorg O Schmid P Saurat JH
Swiss Federal Laboratories for Materials Testing and Research (Empa),Dübendorf,Switzerland Dermato-Toxicology,Swiss Center for Human Applied Toxicology,& Dept. of Dermatology,University Hospi
国际会议
北京
英文
1-4
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）