STRUCTURE-DEPENDENT HORMETIC CYTOTOXICITY INDUCED BY PCB CONGENERS

摘要：

The effects of exposure of Vero cells to polychlorinated biphenyl (PCB)congenes were examined.An ortho-substituted PCB congener (PCB 52)and a coplanar congener (PCB 77)were assessed for their cytotoxicity on Vero cell,with the attempt to assess the possible hormetic biphasic dose-response curve and to compare their structuure-activity relationship.Flow cytometry was used to monitor the changes of biochemical endpoints caused by those two PCB Congeners.Both ortho-substituted and non ortho-substituted coplanar PCB congeners showed the hormetic cytotoxicity:cell proliferation stimulation at low doses,while loss of viability with high dose.Their cytotoxic profile was different along the incubation prolongation.These two different trends might be associated with their genotoxicity and Ah agonist characteristics respectively,which was related whth their chemical structures.

作者: Shen K L Shen C F Dou C M Chen Y X

作者单位: Department of Environmental Engineering,Zhejiang University,Huajiachi Campus,268 Kaixuan Road,Hangzh MOE Key Lab of Environmental Remediation and Ecosystem Health,College of Environmental & Resources S

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-6

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）