CONCENTRATIONS OF DIOXIN-LIKE COMPOUNDS IN THE U.S.POPULATION: AN EVALUATION OF DATA TRENDS AND THE EFFECTS OF DEMOGRAPHIC CHARACTERISTICS ON REFERENT TOTAL TEQ LEVELS
Biomonitoring can be a critical tool in assessing exposure to potentially harmful chemicals. Yet interpretation of biomonitoring data can be complex and requires understanding of temporal trends in chemical body burden and proper interpretation of reference concentrations measured in the general population. In this study, we evaluated data trends for the 2001-2002 and 2003-2004 NHANES PCDD/F and dioxin-like PCB serum concentration data in order to estimate reference levels of total TEQ concentrations for a variety of subpopulations. We also assessed the influence of various demographic characteristics, including geographic region, on concentrations of total TEQ. Lower limits of detection (LODs) for the 2003-2004 survey have allowed for more accurate estimations of background levels of PCDD/Fs and dioxin-like PCBs in the general population. Due either to a result of these lower LODs and/or decreasing exposure of the general population, total TEQ body burden appears to be steadily declining; however, the congeners that contribute the greatest to total TEQ has remained relatively static. As expected, age had the greatest overall effect on total TEQ concentrations, both independently and adjusted for other characteristics such as race/ethnicity and gender, with a clear increasing trend in total TEQ concentrations with increasing age.
Nguyen LM Chen CL Scott LLF
ChemRisk,San Francisco,CA,USA
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）