PERSITENT ORGANOCHLORINE POLLUTANTS: A RISK FACTOR FOR TYPE 2 DIABETES
Persistent organochlorine pollutants (POP), have in several cross-sectional studies shown strong associations with type 2 diabetes. Reversed causality can however not be excluded. The aim of this case control study was to evaluate whether POP concentration is a risk factor for type 2 diabetes. The study was performed within a cohort of women, 50-59 years, from Sweden. Biomarkers for POP exposure, 2,2,4,4,5,5-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p-DDE) were analyzed in stored serum samples, which were collected at the baseline examination when the cohort was established. For 107 out of the 371 cases, serum samples were stored at least three years before their type 2 diabetes was diagnosed. CB-153 and p,p-DDE were not associated with an increased risk to develop type 2 diabetes. However, when only the cases (n=39) that were diagnosed more than six years after the baseline examination and their controls were studied, the women in the highest exposed quartile showed an increased risk to develop type 2 diabetes (OR of 1.6 95％ 0.61, 4.0 for CB-153 and 5.5 95％ CI 1.2, 25 for p,p-DDE). The results confirms that p,pDDE exposure can be a risk factor for type 2 diabetes. Thus, the importance of environmental pollutants must not be neglected.
Anna Rignell-Hydbom Jonas Lidfeldt Hannu Kiviranta Panu Rantakokko G(o)ran Samsioe Carl-David Agardh Lars Rylander
Division of Occupational and Environmental Medicine,Department of Laboratory Medicine,Lund Universit Unit on Vascular Diabetic Complications,Department of Clinical Science,Lund University,University Ho National Institute for Health and Welfare (THL),Neulanen Research Centre FI-70701 Kuopio,FINLAND Department of Obstetrics and Gynaecology,University Hospital Lund,SE-221 85 Lund,Sweden
国际会议
北京
英文
1-5
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）