INFLUENCE OF THE SOLVENT QUALITY USED FOR SAMPLE PREPARATION ON THE AhR MEDIATED PROCEPT(R) ASSAY MEASUREMENT OF DIOXIN AND DIOXIN-LIKE COMPOUNDS

摘要：

The influence of solvent grade quality on the response of a DNA-binding AhR-mediated assay used for screening dioxins was investigated. Our results demonstrated a very critical impact of this parameter with both strong agonistic and antagonistic effects observed for any tested solvent lot. A small silver nitrate silica column partly removed these interfering compounds and then can be recommended as final purification step. Some preferable grades can be identified and selected in order to guarantee the best possible performances. However, it appears necessary to test every new lot, even if a grade previously appeared compliant.

作者: Cariou Ronan McAlister Daniel R Marchand Philippe Fern Michael J Antignac Jean-Philippe Le Bizec Bruno

作者单位: LABoratoire dEtude des Résidus et Contaminants dans les Aliments (LABERCA),Ecole Nationale Vétérina Eichrom Technologies,LLC,1955 University Lane,Lisle,IL 60532,United States

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-6

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）