PREDICTION OF THE PCDD/F, dl-PCB, AND TOTAL 2005-WHO-TEQ VALUES ON THE BASIS OF SIX CONGENER CONCENTRATIONS IN FISH:TOWARD A NEW SCREENING STRATEGY FOR THE CONTROL?
Current European regulation related to polychlorinated dibenzo-p-dioxins/furans (PCDD/F) and dioxin-like polychlorinated biphenyls (dl-PCB) in food is based on WHO-TEQ values. For confirmatory purpose, Gas chromatography coupled with high resolution mass spectrometry (GC-HRMS) according to the isotope-dilution method is usually the method of choice for precisely measuring the 29 target congener in three separated fractions. Time and cost related to these analyses are very significant. Diverse kinds of screening concepts can be envisaged: bioanalytical techniques or still GC-MS related techniques. In the present study, we elaborated and validated a prediction model fit for the GC-MS screening approach in fish, based on the measurement of 4 PCDD/F and 2 co-planar dl-PCB congeners, potentially analyzable in a single extracted fraction. Consequent independent datasets were used for model elaboration (n=108) and validation (n=363, n=357 and n=6), and performances of the model were evaluated in terms of robustness, prediction capability and false negative/positive rates.
Ronan Cariou Philippe Marchand Ana(i)s Véisseau Aline Brosseaud Dominique Bertrand El Mostafa Qannari Jean-Philippe Antignac Bruno Le Bizec
LABoratoire dEtude des Résidus et Contaminants dans les Aliments (LABERCA),Ecole Nationale Vétérina Unité de Sensométrie et de Chimiométrie,Ecole Nationale dIngénieurs des Techniques des Industries A
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）