Effects of dioxins, PCBs and PBDEs on immunology and haematology in adolescents
Dioxins and PCBs are environmental pollutants, proven to be immunotoxic. In this longitudinal cohort, at birth and at follow-up during childhood, immunological and haematological effects were seen, prompting us to perform a new follow-up during adolescence. Methods: Vena puncture was performed to assess haematological (Haemoglobin, thrombocytes, thrombopoietin) and immunological (leukocytes, leukocyte differentiation) parameters and the current serum levels of dioxin, dl-PCBs and PBDEs. Results: A decrease in the number of polymorphic neutrophils was found in adolescents with higher dl-PCBs in their serum (p=0.021). No relationship with leukocyte counts, thrombocytes, haemoglobin or thrombopoietin levels was seen. Similarly, we found no relationship between prenatal, nor current, dioxin levels and the hematological and the immunological parameters determined. The ΣPBDEs were negatively associated with the number of lymphocytes (p=0.01) and positively with the haemoglobin concentration (p=0.003). Conclusion: These effects on the innate immunity by current levels of dl-PCBs and on the adaptive immunity by PBDEs are disconcerting, especially as the dl-PCB (0.04-7.8 WHOTEQ pg/g lipid, mean: 2.2 WHOTEQ pg/g lipid) and ΣPBDE levels (mean 14.04 ng/g lipid, including one outlier with a sum of 73.6 ng/g lipid) were not exceptionally high.
Marike M.Leijs Janna G.Koppe Kees Olie Wim M.C.van Aalderen Pim de Voogt Gavin W.ten Tusscher
Department of Paediatrics and Neonatology,Emma Childrens Hospital Academic Medical Centre,Amsterdam Ecobaby Foundation,Loenersloot,Netherlands IBED/ESS,University of Amsterdam,Netherlands Department of Paediatrics and Neonatology,Emma Childrens Hospital Academic Medical Centre,Amsterdam IBED/ESS,University of Amsterdam,Netherlands Ecobaby Foundation,Loenersloot,Netherlands Department of Paediatrics and Neonatology,Westfriesgasthuis,Maelsonstraat 3,1624 NP Hoorn,Netherland
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）