DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MATERNAL SERUM AND CORD BLOOD SAMPLES USING ACCELERATED SOLVENT EXTRACTION AND GC/EI-MS/MS
Accelerated solvent extraction (ASE) was used for the extraction of polybrominated diphenyl ethers (PBDEs) from biological matrices. The ASE technique proved to be efficient, simple, and rapid. Very low detection limits were achieved through the combination of ASE and GC/EI-MS/MS for the analysis of PBDEs in maternal serum (n = 101) and umbilical cord blood (n =104) samples. Ten PBDE congeners were analyzed in this study: the tri-(BDE 17, 28), tetra-(BDE 47, 66), penta-(BDE 99, 100), hexa-(BDE 153, 154), hepta-(BDE 183), and deca-(BDE-209). The mean recovery ranged from 87％ to 127％ for the PBDEs under investigation, with the exception of the deca-(BDE-209). Data for the latter were not reported in this study because of the high background interference observed in processing the method blank samples. PBDE-47 was found to be the major congener in both maternal serum and umbilical cord blood, with a mean concentration of 44.3, 44.7 and 76.7ng/g lipid for maternal serum at mid pregnancy, maternal serum at delivery, and in umbilical cord blood, respectively.
Cariton Kubwabo Sandra Gregorovich Rocio Monroy Katherine Morrison Stephanie Atkinson Brian Stewart Koon Teo Warren G.Foster
Research and Radiation Directorate,Health Canada,Ottawa,Ontario,Canada Department of Obstetrics & Gynecology,McMaster University,Hamilton,Ontario,Canada Department of Pediatrics,McMaster University,Hamilton,Ontario,Canada Department of Medicine,McMaster University,Hamilton,Ontario,Canada
国际会议
北京
英文
1-7
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）