CONCENTRATIONS AND SPECIATION OF POLYBROMINATED DIPHENYL ETHERS (PBDE) IN HUMAN AMNIOTIC FLUID
Polybrominated diphenyl ethers (PBDEs) are persistent organic chemicals used as flame retardants in textiles, plastics, and consumer products. Many of the 209 PBDE congeners have been classified as persistent organic pollutants at the 4th meeting of the Convention of Parties of the Stockholm Convention on Persistent Organic Chemicals. Although PBDE accumulation in humans has been noted since the 1970s, few studies have investigated PBDEs within the gestational compartment and none to date has identified levels in amniotic fluid. This study reports congener-specific PBDE concentrations in second-trimester amniotic fluid from fifteen women in southeast Michigan, USA. BDEs 17, 28, 47, 49, 66, 71, 75, 85, 99, 100, 138, 153, 154, 166, 183, 190, 203, 206, 207, 208 and 209 were measured by GC/MS. The average total PBDE concentration was 3,795 pg/ml amniotic fluid (range 337 – 21,842 pg/ml). High levels of both higher and lower brominated PBDEs were identified. The most abundant congeners were BDE-138 (15％ of the total BDE), 207 (15％), 47 (10％), 208 (9.5％), and deca (8.4％). BDEs 47 and 99 were identified in each sample. These results show that high PBDE concentrations in amniotic fluid are common, and they suggest that amniotic fluid may participate in the transfer of PBDEs to the fetus, a previously undocumented exposure route. The relatively high levels of PBDEs found in the human gestational compartment warrant further investigations of exposure pathways and potential impacts to birth outcomes and perinatal health.
Polybrominated diphenyl ethers (PBDEs) amniotic fluid human exposure pregnancy
Miller MF Chernyak SM Domino SE Batterman S Loch-Caruso R
Department of Environmental Health Science,School of Public Health,University of Michigan,Ann Arbor, Department of Obstetrics and Gynecology,University of Michigan,Ann Arbor,Michigan 48109
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）