EFFECT OF PRENATAL EXPOSURE TO PFOS ON GENE EXPRESSION IN DEVELOPING RAT BRAIN
Perfluorooctanesulfonate (PFOS), a persistent and bioaccumulative compound, is widely distributed in the environment including in the tissues of wildlife and humans. The potential neurobiological toxicity has been reavealed recently, however, the mechanism of action of PFOS remains unclear. To further explore the molecular mechanism underlying the developing neurobiological action of PFOS, two of the Illumina RatRef-12 Expression BeadChips were used to identify alterations in brain gene expression by PFOS exposure in Wistar rat pups at postnatal day(PND)1. Dams were treated with PFOS at 3.2 mg/kg feed from gestational day 1 to the end of experiment(PND1). Genes that were significantly (P <0.05) affected were primarily genes for cell cycle, PPAR signaling, Long-term potentiation, calcium signaling pathway, cell communication, GnRH signaling pathway, or genes involved in hormone regulation. No obvious morphological deficiency was observed. Results of this study indicated that prenatal exposure to PFOS caused developmental neurotoxicity, and one possible mechanism for it is through the disturbance of hormone regulation.
Wang F Q Liu W Jin Y H
School of Environmental and Biological Science and Technology,Dalian University of Technology,Key Laboratory of Industrial Ecology and Environmental Engineering,Ministry of Education,Linggong Road 2,Dalian 116024,China
国际会议
北京
英文
1-8
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）