SYNTHESIS AND IDENTIFICATION OF HYDROXYLATED POLYBROMINATED DIPHENYL ETHERS IN HUMAN BLOOD
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) can be of a natural origin or be formed as metabolites and transformation products of polybrominated diphenyl ethers (PBDEs). PBDEs have been widely used as flame retardants in for example electronic devises and furniture and their metabolites have been detected in animal and human blood. In this study, two pentabromo-, two hexabromo- and one heptabromo-OH-PBDE and the corresponding methoxylated polybrominated diphenyl ethers (MeO-PBDEs) were synthesised via brominated diaryliodonium salts. These reference MeO-PBDEs, 2,2,4,4,5-pentabromo-3-methoxy-diphenyl ether (3-MeO-BDE- 99), 2,2,4,4,6-pentabromo-3-methoxy-diphenyl ether (3-MeO-BDE-100), 2,2,4,4,5,6-hexabromo-3-methoxydiphenylether (3-MeO-BDE-154) and 2,2,3,4,5,5,6-heptabromo-4-methoxy-diphenyl ether (4-MeO-BDE-187) and 2,2,4,4,6,6-hexabromo-3-methoxy-diphenyl ether (3-MeO-BDE-155), where then used for tentative identification of methyl derivatized OH-PBDEs (MeO-PBDEs) in human blood from children working at a municipal waste disposal site in Managua, Nicaragua. Using gas-chromatography mass spectrometry (GC/MS) in electron capture negative ionization (ECNI) mode, scanning for bromide ions (m/z = 79, 81), we could observe that the retention times of each one of the MeO-PBDEs matched peaks in the chromatogram from the blood serum sample.
Rydén A Nestor G Athanasiadou M Cuadra S N Jakobsson K Bergman (A) Marsh G
Department of Environmental Chemistry,Stockholm University,Svante Arrhenius v(a)g 12,SE-10691 Stockh Department of Environmental Chemistry,Stockholm University,Svante Arrhenius v(a)g 12,SE-10691 Stockh Facultad de Ciencias Médicas,Universidad Nacional Autónoma de Nicaragua-Managua (UNAN-Managua),Apart Department of Occupational and Environmental Medicine,Lund University Hospital,SE-221 85 Lund,Sweden
国际会议
北京
英文
1-5
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）