IDENTIFICATION OF EMERGING ENVIRONMENTAL CONTAMINANTS AND BIOMARKERS IN HUMAN BODY FLUID USING ACCURATE MASS MEASUREMENT BY HRGC-HRMS

摘要：

Accurate mass measurement, proposed molecular or fragment formula, and isotope profile calculation are effective tools for identification of emerging contaminants, selection of accurate masses for monitoring them, and identification of potential interferences. We used these tools to develop a method to determine the dialkyl phosphate metabolites (DAPs) of organophosphate (OP) insecticides in human urine. This paper presents the detailed techniques of accurate mass measurement and derivation of molecular or fragment formula, using tools provided by the vendor or developed by ourselves. We discuss other techniques related to accurate mass measurement using a high resolution gas chromatograph-high resolution mass spectrometer (HRGC-HRMS), and present a new method for the measurement of DAPs with HRGC-HRMS.

作者: She Jianwen Behniwal Paramjit Ramage Robert Zahedi Rana Barley Frank

作者单位: Biochemistry Section,Environmental Health Laboratory Branch California Department of Public Health,Richmond,CA 94804,USA

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-5

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）