BIOASSAY DIRECTED DETECTION OF BROMINATED DIOXINS IN THE FEED ADDITIVE CHOLIN CHLORIDE
During the past two years, several samples of the feed additive cholin chloride tested positive in the DR CALUX(R) assay. However, GC/MS analysis could not confirm the presence of dioxins or dioxin-like PCBs. Examination by GC-TOFMS revealed the presence of various brominated flame retardants (BFRs), such as PBDEs and 2,4,6-tribromophenol, but also the new BFR Octabromo-1,3,3-trimethylphenyl-1-indan (OBIND). These compounds could not explain the positive CALUX-result but indicated the presence of brominated dioxins. This was confirmed by GC/MS analysis, showing in particular 2,3,7,8-TBDF. This study shows that the combined use of a bioassay and chemical analytical methods may result in the identification of novel risks introduced into the food chain.
Wim Traag Alexander Kotz Guido van der Weg Rainer Malisch Ron Hoogenboom
RIKILT Institute of Foodsafety,Wageningen UR,P.O. Box 230,6708PD Wageningen,The Netherlands EU Community Reference Laboratory (CRL) for Dioxins and PCBs in Feed and Food (at Chemisches und Vet
国际会议
北京
英文
1-4
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）