SERUM DIOXIN CONCENTRATIONS AND TIME TO PREGNANCY
On July 10, 1976, as a result of a chemical explosion, residents of Seveso, Italy, experienced the highest levels of TCDD in a human population. Twenty years later, we initiated the Seveso Womens Health Study (SWHS), a retrospective cohort study of the reproductive health of the women. We examined the association between TCDD exposure and fertility as measured by time to pregnancy (TTP). The SWHS cohort comprises 981 women who were 0 to 40 years in 1976, resided in the most contaminated areas, and had adequate archived sera collected soon after the explosion. Individual serum TCDD exposure was measured by high-resolution mass spectrometry. We examined the relation of serum TCDD with TTP using a discrete-time analogue of the Cox proportional hazards model. Of 981 women, 472 attempted pregnancy post-explosion, and 278 had a planned or non-contracepted pregnancy resulting in a live birth. A 10-fold increase in serum TCDD was associated with a 25％ increase in TTP (adjusted–fecundability Odds Ratio = 0.75, 95％CI: 0.60, 0.95), and suggests TCDD exposure may be associated with reduced fertility in the Seveso cohort.
Eskenazi B Warner M Marks A Samuels S Needham L Brambilla P Mocarelli P
School of Public Health,University of California,Berkeley,CA,USA School of Public Health,State University of New York at Albany,Albany,NY,USA Division of Environmental Health Laboratory Science,National Center for Environmental Health,Centers Department of Laboratory Medicine,University of Milano-Bicocca,School of Medicine,Hospital of Desio,
国际会议
北京
英文
1-3
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）