ASSESSMENT OF DIOXIN-LIKE TOXICITY IN SOILS CONTAMINATED BY A CHLORALKALI PROCESS AND A LEBLANC FACTORY
Contaminated soils from a former chloralkali process and former Leblanc factory (with integrated chlorine production) with high levels of PCDD/PCDF and a wide range of other polychlorinated aromatic compounds were screened for their dioxin-like toxicity. As bioassays the permanent rat hepatoma cell line H4IIe and the permanent fish liver cell RTL-W1 obtained from Rainbow trout were used, and Bio-TEQ with and without oxidation and fractionation, respectively, were compared with chemical TEQ-values from PCDD/PCDDF instrumental analysis. Using this screening strategy it was revealed that the complex mixture of aromatic and polychlorinated aromatic compounds elicit significant agonistic and antagonistic effects. While for most samples the majority of the Bio-TEQ could be explained by PCDD/PCDF concentrations determined analytically, only approximately 10％ of the Bio-TEQ could be explained by PCDD/PCDFs in some samples, even after oxidation and the routine fractionation for determining dioxin-like toxicity of the coplanar/dioxin fraction. The current study demonstrates the necessity of screening contaminated sites/processes where elemental chlorine has been produced. As evaluation tool, a combination of biological methods and a comprehensive instrumental screening is recommended.
Anne J.Schneider Markus Brinkmann Andrea Gerstner Jan W(o)lz Sebastian Heger Roland Weber Magnus Engwall Thomas-Benjamin Seiler Henner Hollert
Institute for Environmental Research,RWTH-Aachen,Germany POPs Environmental Consulting G(o)ppingen,Germany MTM Institute,University of (O)rebro,Sweden MTM Institute,University of (O)rebro,Sweden
国际会议
北京
英文
1-5
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）