An improved analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods and separation of taurodeoxycholic acid from perfluorooctane sulfonate using an ion exchange column
A method using acetonitrile and OASIS WAX(R) solid phase extraction (SPE) cartridges for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluorooctanesulfonamide; N-ethyl perfluorooctanesulfonamide; N-ethyl perfluorooctanesulfonamidoacetate; perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2)) in whole blood was developed. Matrix recoveries of the developed methods ranged from 70 to 120％. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Separation of possible inferences such as taurodeoxycholic acid (TDC) from PFOS was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood from different animals.
Yeung Leo W.Y. Taniyasu Sachi Kannan Kurunthachalam Xu Della Z.Y. Guruge Keerthi S. Lam Paul K.S. Yamashita Nobuyoshi
National Institute of Advanced Industrial Science and Technology (AIST),16-1 Onogawa,Tsukuba,Ibaraki National Institute of Advanced Industrial Science and Technology (AIST),16-1 Onogawa,Tsukuba,Ibaraki Wadsworth Center,New York State Department of Health and Department of Environmental Health Sciences Department of Biology and Chemistry,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong Safety Research Team,National Institute of Animal Health,Kannondai 3-1-5,Tsukuba,Ibaraki 305-0856,Ja
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）