ISOTOPE DILUTION QUANTITATION OF PAH METABOLITES AT TRACE LEVELS USING A GC-MSMS MRM METHOD
Introduction Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from various occupational, environmental, medicinal, and dietary sources. PAH metabolites in human urine can be used as biomarkers to assess exposure to PAHs. PAH metabolites have been detected in human urine as a number of hydroxylated PAHs. Metabolites are found at low levels in human urine even in persons without apparent occupational or smoking exposure. Although measurement of these metabolites is used in assessing recent exposure to PAHs, their value as predictive markers of biological effect or health outcomes is currently being evaluated. In order to perform comprehensive epidemiological studies where multiple metabolites of several PAHs can be measured and compared in low-dose urine samples, fast and robust methods are needed to measure many analytes.
PAH metabolites urine biomarker isotope dilution quantitation GC-MSMS multiple reaction monitoring MRM
Lovisa C.Romanoff Frank Theobald Hans-Joachim Huebschmann
Centers for Disease Control and Prevention,Atlanta,GA,USA Environmental Consulting,Cologne,Germany Thermo Fisher Scientific,Austin,TX,USA
国际会议
北京
英文
1-4
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）