Detection of Benzoapyrene-DNA Adducts for Human Biomonitoring by Capillary Electrophoresis-Laser Induced Fluorescence

摘要：

DNA adducts plays a critical role in carcinogenic process. However it is a great challenge to specifically and sensitively detect the trace of DNA adducts occurred in vivo. Here we present a highly sensitive capillary electrophoresis-laser induced fluorescence (CE-LIF) method for detection of the trace levels of benzoapyrene diol epoxide (BPDE)-DNA adducts, which has directly link with lung cancer. The developed CE-LIF immunoassay for BPDE-DNA adducts was applied for human biomonitoring by analyzing human leukocyte DNA.

作者: WANG Zhixin WANG Xiaoli DONG Shaoxia JIN Yinlong WANG Hailin

作者单位: State Key Laboratory of Environmental Chemistry and Eco-toxicology,Research Center for Eco-Environme nstitute for Environmental Health and Related Product Safety,Chinese Center for Disease Control and

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）