FLUORESCENCE STUDY ON THE INTERACTIONS OF HYDROXYLATED POLYBROMINATED DIPHENYL ETHERS WITH THYROID HORMONE TRANSPORT PROTEINS IN VITRO

摘要：

The study on interaction between hydroxylated PBDEs and transporter proteins is very important to evaluate the toxicity of PBDEs. In the present study, the interaction of hydroxylated metabolites of polybrominated diphenyl ethers and thyroxine transporter proteins had been characterized by fluorescent method. Binding affinities of hydroxylated PBDEs with two thyroxine transporter proteins were measured. The structure-activity relationships of different hydroxylated PBDEs with thyroxine transporter proteins were also investigated.

作者: Jie Cao Yin Wei Yu Yang Liang-Hong Guo

作者单位: State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-environmen State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-environmen

会议类型: 国际会议

会议名称: 29th International Symposium on Halogenated Persistent Organic Pollutants(第29届国际持久性有机污染物研讨会)(2009国际二噁英大会)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-08-24（万方平台首次上网日期，不代表论文的发表时间）