TEF CONCEPT AND ENVIRONMENT: SCIENCE MEETS POLICY
The application of the TEF concept is very helpful for risk assessment to evaluate the toxicity of mixtures of dioxin-like compounds to mammalians including humans. The calculated TEQ depends on the TEF models used, bearing in mind that the TEQ for mammalians is not derived to show the real toxicity for biota, especially in conifer shoots the TEQ does not reflect the toxicity for plants. The congener pattern changes within the food chain and differs between species. In risk management the regulations are based on different calculations of limit values. Emission and environment is mostly regulated with I-TEQ. Dioxin-like PCBs are therefore not included. Feed and food regulation in the European Union are based on WHO-TEQ (1998). For protecting the environment, looking for sources, transfer and carry over congener specific data are necessary. Therefore all analytic results should be available on single congener base. The TEF Concept is a useful tool for assessing and managing the risk for a group of similar acting chemicals. Therefore it is a good model for other chemical groups like estrogenic disruptors which bind on the same receptor or for phthalates, which are more and more used as a mixture.
Rappolder Marianne
Federal Environment Agency,Germany,06844 Dessau-Rosslau,W(o)rlitzer Platz 1
国际会议
北京
英文
1-5
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）