MULTIASSESSMENT of ECOSAFETY of SYNTHETIC PYRETHROIDS
The increasing release of synthetic pyrethroids into the environment dictates attention to a better understanding of enantioselectivity in their human and ecotoxicological effects. Although divers endpoints have been considered in many recent studies, there is little effort for discerning the connection between different processes, and as such, our current knowledge about the ecosafety is rather scattered and incoherent. In this study, we simultaneously evaluated two synthetic pyrethroids lambda-cyhalothrin (LCT) and (Z)-cis-bifenthrin (cis-BF) in aquatic chronic toxicity (D. Magana), immunotyoxicity to macrophage cells (RAW264.7). Our results showed that the lowest observed effective concentration (LOEC) and the non-observed effective concentration (NOEC) of cis-BF to D. magna were 0.02 and 0.01 μg L-1, respectively. Meanwhile, increased endogenous ROS and DNA damage as co-mediators of LCT-induced cytotoxicity in macrophages. Given that many biological processes are interrelated, ecosafety of synthetic pyrethroids may follow specific patterns that can be revealed via integrative assessments as demonstrated in this study.
Zhao Meirong Wang Cui Zhang Quan
College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou 310032,China
国际会议
北京
英文
1-6
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）