BIOLOGICAL AND TOXICOLOGICAL CONSEQUENCES OF Ah RECEPTOR ACTIVATION: JUST HOW COMPLICATED CAN ONE RECEPTOR GET?
The Ah receptor (AhR) is a ligand-dependent transcription factor receptor that mediates a wide range of biological and toxicological effects produced by a structurally-diverse synthetic and naturally-occurring chemicals. While the overall mechanism of action of the AhR has been extensively studied and involves a classical nuclear receptor mechanism of action (i.e. ligand-dependent nuclear localization, protein dimerization, binding of liganded receptor as a dimer to its specific DNA recognition sequence and activation of gene expression), details of the exact molecular events that result in most AhR-dependent biochemical, physiological and toxicological effects are generally lacking. While ongoing research efforts continue to describe an everexpanding list of ligand- and tissue-specific and AhR-dependent diverse biological and toxicological effects and seemingly complicate the story even more. However, these same studies are also identifying and characterizing new pathways and molecular mechanisms by which the AhR exerts its actions and both are providing insights and questions regarding the diversity in responses following ligand-dependent activation of the AhR signal transduction system.
Denison MS Zhao B Bonati L
Department of Environmental Toxicology,University of California,Davis,CA 95616 USA Department of Environmental Toxicology,University of California,Davis,CA 95616 USA Research Center f Dipartimento di Scienze dellAmbiente e del Territorio,Università degli Studi di Milano-Bicocca,Mila
国际会议
北京
英文
1-4
2009-08-24（万方平台首次上网日期，不代表论文的发表时间）