Silicon Nitride Surface Modification and Cell Adhesion

摘要：

Silicon microelectrode arrays (Si MEAs) have great potential in recording of neural activity; the biocompatibility of silicon nitride has gained much attention as a part of Si MEAs. In this study, we used alternating polycations, polyethyleneimine (PEI), and polyanions, gelatin, to fabricate multilayer films built up by LbL deposition on silicon nitride wafers. Then the samples surfaces were characterized by contact angle system and atomic force microscopy (AFM). The amount of proteins adsorbed on silicon nitride and modified silicon nitride were measured by a modified Coomassie brilliant blue (CBB) protein assay. Cell culture results showed that the modified silicon nitride could increase the adhesion ability of the hippocampal neurons.

关键词： Silicon Nitride Modification Layer-by-layer Assembly Hippocampal Cells

作者: Yi ZHAO XiaoYing LV ZhengLin JIANG Xia LI Yan HUANG ZhiGong WANG

作者单位: State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096,China Jiangsu Key Laboratory of Neuroregeneration, and Institute of Nautical Medicine,Nantong University, Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China

会议类型: 国际会议

会议名称: 2008年中美材料国际研讨会

会议地点: 重庆

会议语种:英文

页码: 1022-1025

在线出版日期: 2008-06-09（万方平台首次上网日期，不代表论文的发表时间）