Biocompatibility of Chitosan/heparin Multilayer Coating on NiTi Alloy
Nickel Titanium alloy has been used widely in clinical iatrology for years because of its unique shape memory capability, proper elasticity and considerable biocompatibility. But as an implanted material, its possible release of Ni ions which might cause toxic effect and its improvable biocompatibility draw attentions of researchers. In this study, chitosan/heparin multilayer is coated on NiTi shape memory alloy by electrostatic self-assemble method. Field emission scanning electron microscopy (FE-SEM), contact angle test is used to show its surface character; hemolysis test, dynamic clotting time experiment and platelet binding test are utilized to investigate the blood compatibility of the materials. The results reveal that the hydrophilic character of the coated one is better than the substrate, and blood compatibility of NiTi is improved by coating treatment.
Biocompatibility Chitosan/heparin Electrostatic Self-assemble NiTi
Ping DONG Lingwei YUAN Weichang HAO Yayi XIA Guozu DA Tianmin WANG
Center of Material Physics and Chemistry, Beihang University, Beijing 100083, China Orthopaedic Research Institute, The Second Hospital of Lanzhou University,Lanzhou 730030, China Seemine Company, Lanzhou 730030, China
国际会议
重庆
英文
1179-1182
2008-06-09（万方平台首次上网日期，不代表论文的发表时间）