Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane
In this study, a novel nitric oxide (NO) endogenously releasing polyurethane (PU) material, i.e. PU-g-L-cysteine(PU-Cys), was synthesized by grafting L-cysteine on the film surface. Fluorescence analysis and a BCA method were used to characterize qualitatively and quantitatively the grafted L-cysteine. The results showed that L-cysteine was successfully immobilized on the PU film surface and the density of L-cysteine grafted was calculated to be 15.3 nmol/cm2. The NO releasing behavior study of PU-Cys film demonstrated that endogenous NO could be continuously released from PU-Cys film and the accumulated releasing amount within 3h added up to 1.06 nmol/cm2. The releasing rate of NO was well matchable to the self-releasing rate of resting platelets in human body. The results of dynamic blood clotting test and hemolysis ratio measurement showed that PU-Cys film had a better haemocompatibility than PU film, which might be the result of endogenously released NO inhibiting platelet adhesion and thrombus formation. Therefore, PU-Cys with the property of endogenous NO releasing is expected to be an ideal blood compatibility material in clinical application.
Polyurethane L-cysteine Grafting Nitric Oxide Haemocompatibility
Jianhao ZHAO Mei TU Rong ZENG Jie GENG Zhengang CHA Changren ZHOU
Department of Material Science and Engineering, College of Science and Engineering,Jinan University, Department of Material Science and Engineering, College of Science and Engineering,Jinan University, Engineering Research Center of Artificial Organs and Materials, Ministry of Education,Jinan Universi
国际会议
重庆
英文
1237-1243
2008-06-09（万方平台首次上网日期，不代表论文的发表时间）