Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release

摘要：

Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline hydrochloride (TH) was loaded onto the electrospun fibers through after-treatment method. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and in vitro dissolution tests were carried out to characterize the medicated electrospun fibers. The SEM and FTIR results clearly showed the difference between the UPM / PHBV and UPM/ PHBV/ PVPelectrospun fibers. The pharmaceutical tests results indicated that the fibers had good drug-loaded capability and sustained-release properties. The as-prepared fibers might find possible applications as wound dressings or transdermal drug delivery systems.

关键词： Electrospinning Sustained Drug Release Crosslinked

作者: Jingjing ZHANG Jun LIU Hao YU Yu ZHANG Meifang ZHU Yanmo CHEN

作者单位: State Key Laboratory for Modification of Chemical Fibers and Polymeric Materials,College of Material Scienceand Engineering,Donghua University, Shanghai 200051, China

会议类型: 国际会议

会议名称: 2008年中美材料国际研讨会

会议地点: 重庆

会议语种:英文

页码: 1331-1334

在线出版日期: 2008-06-09（万方平台首次上网日期，不代表论文的发表时间）