Prediction of Shear Stress Distribution throughout 3D Bone Scaffold in Perfusion Environment

摘要：

In tissue engineering, mechanical stimuli play an important role in the cell proliferation process. This paper developed a 3D model to analyze the shear stress distribution in porous scaffold dynamically. a series of 3D scaffolds with different porosity level (60%-80%) were constructed to generate a large amount of shear stress distributions in the CFD tool. The simulations revealed that average shear stress is linear with velocity and the porosity has a strong influence of average shear stress. A linear prediction model is built on the analyzing data, which can demonstrate relationships between shear stress distribution on the inter surface of the 3d scaffold and the perfusion conditions.

关键词： Bone scaffold Shear stress distribution Perfusion bioreactor CFD Porosity

作者: Yuan Yao Yongwei Yu Jun Guo Yi Qian Jiawei Wang

作者单位: Rapid Manufacturing Engineering Center Shanghai, China

会议类型: 国际会议

会议名称: 2010 International Conference on Image Analysis and Signal Processing(2010 图像分析与信号处理国际会议 IASP 10)

会议地点: 厦门

会议语种:英文

页码: 51-54

在线出版日期: 2010-04-12（万方平台首次上网日期，不代表论文的发表时间）