A Method for Querying Conserved Subnetwork in a Large-Scale Biomolecular Network

摘要：

To uncover conserved pathways using systems biology methods, comparing various kinds of networks among different species or within a species becomes an increasingly important problem. With more and more molecular data being available, most of the current methods cannot deal with the large-scale networks owing to the computational scale limitation on a single PC or workstation. In this paper, we adopted an Immediate Neighbors-in-first Method for the biomolecular network querying problem. In contrast to other methods, we developed the parallel computing algorithm to treat large-scale networks. The efficient parallel performance of the present method is shown by Parkinsons Disease related protein interaction network.

作者: Jiang Xie Weibing Feng Shihua Zhang Songbei Li Guoyong Mao Luwen Zhang Tieqiao Wen Wu Zhang

作者单位: School of Computer Engineering and Science,Shanghai University,Shanghai 200072 Institute of Systems School of Computer Engineering and Science,Shanghai University, Shanghai 200072 Academy of Mathematics and Systems Science, CAS, Beijing 100080 Department of Electronic Information and Electric Engineering,Changzhou Institute of Technology, Cha Institute of Systems Biology, Shanghai University, Shanghai 200444 School of Computer Engineering and Science,Shanghai University, Shanghai 200072 Institute of Systems

会议类型: 国际会议

会议名称: The Second International Conference on High Performance Computing and Applications(第二届高性能计算及应用国际会议)

会议地点: 上海

会议语种:英文

页码: 473-478

在线出版日期: 2009-08-10（万方平台首次上网日期，不代表论文的发表时间）