Inflammatory and cytotozic assessment of ambient fine particulate matter: A review of recent studies
Daily exposure to airborne particulate matter (PM) pollution in urban zones is associated with an increase in morbidity and mortality. This is certified by numerous epidemiological studies on associations between PM exposure and acute and chronic cardiopulmonary diseases. The biological mechanisms behind these associations are not fully understood,but in vitro research has indicated that proinflammatory cytokine production and oxidative stress play key roles;meanwhile these biological effects are associated with various organic and inorganic components of PM mixture.In this review,the results are summarized of the most recent studies investigating physical and chemical characteristics of PM in relation to its toxicological activity. This evaluation shows that,in general,the fine size fractions of PM2.5 have higher toxicity,contain higher concentrations of extractable toxic matter (comprising a wide spectrum of chemical substances,such as transition metals,polycyclic aromaric hydrocarbons,and baetcrial components),and possess a relatively high radical-generating capacity. Also,associations between chemical characteristics and PM toxicity tend to be stronger for PM2.5 than PM10.Most importantly,differences in PM toxicity are not necessarily related to PM mass concentrations. This implies that PM regulatory strategies, especially in China,should take both mass and compositions of PM2.5 into account. Therefore, future research should aim at establishing the relationship between toxicity in relation to particle components and their specific sources.
Ambient particulates PM2.5 Inflammation Cytotozicity Radical formation Chemical composition
Yu Shang Tong Zhu Feng Tian Chenyong Chen
Institute of environmental pollution and health,College of Environment and Chemical Engineering,Shan Institute of environmental pollution and health,College of Environment and Chemical Engineering,Shan
国际会议
International Conference on Environment Simulation and Pollution Control(第六届环境模拟与污染控制学术研讨会)
北京
英文
137
2009-11-01（万方平台首次上网日期，不代表论文的发表时间）