Aptamer-conjugated dendrimer-modified quantum dots for glioblastoma cells imaging
Targeted quantum dots have shown potential as a platform for development of cancer imaging. Aptamers have recently been demonstrated as ideal candidates for molecular targeting applications. In present work, polyamidoamine dendrimers were used to modify surface of quantum dots and improve their solubility in water solution. Then, dendrimer-modified quantum dots were conjugated with DNA aptamer, GBI-10, can recognize the extracellular matrix protein tenascin-C on the surface of human glioblastoma cells. The dendrimer-modified quantum dots exhibit watersoluble, high quantum yield, and good biocompatibility. Aptamer-conjugated quantum dots can specifically target U251 human glioblastoma cells. High-performance aptamer-conjugated dendrimers modified quantum dot-based nanoprobes have great potential in application such as cancer imaging.
Zhiming Li Peng Huang Rong He Xiaomin Zhang Chenchen Bao Qiushi Ren Daxiang Cui
National Key Laboratory of Nano/Micro Fabrication Technology,Key Laboratory for Thin Film and Microf National Key Laboratory of Nano/Micro Fabrication Technology,Key Laboratory for Thin Film and Microf Institute for Laser Medicine & Biophotonics,School of Life Sciences and Biotechnology,Shanghai Jiao
国际会议
The 8th China International Nanoscience and Technology Symposium(2009第八届中国国际纳米科技湘潭研讨会Cinsts09)
湖南湘潭
英文
1-4
2009-10-23（万方平台首次上网日期，不代表论文的发表时间）