Evaluation of Small Animal Imaging with Different High Voltage, Filter Thickness and Tube Currency
A panel detector based animal x-ray micro computed tomography (micro-CT) system has been developed. The micro-CT system consists of a CsI flat-panel x-ray detector with a field-of-view of 43×43cm2, a microfocus x-ray source, a rotational subject holder and a parallel data processing system. A model for generating x-ray spectra for the X-ray tube used in this micro-CT system was presented. The transport of electron and photon was simulated by Monte Carlo code PENELOPE. A platform based on Matlab was developed in our laboratory which allowed calculating beam quality parameters, including average energy of X-ray beam, change of transmitting rate and input X-ray fluence. The factors which influence on the signal difference to noise ratio (SDNR) of micro-CT were investigated to fix the scanning protocol for animal imaging. A rat was scanned using the micro-CT system with different high voltage, tube currency, filter thickness and exposure time. The whole angle circle scan track and FDK algorithm were used to reconstruct the images. The results of signal difference to the noise ratio (SDNR) of the bone, soft tissue and lung were presented and analyzed in this article.
small animal imaging CT system imaging performance monte carlo simulation
JIA Peng-Xiang YAN Bin LI Lei CHEN Jian ZHANG Feng BAO Shang-Lian
Beijing City Key Lab of Medical Physics and Engineering, Peking University, Beijing, 100871 Information Engineering University, Zhenzhou, 450002
国际会议
南京
英文
492-499
2009-10-23（万方平台首次上网日期，不代表论文的发表时间）