Pharmacological research of acetylsalicylic acid,chlorpropamide and acizol transdermal therapeutic systems made of biocompatible materials

摘要：

Pharmacological properties of acetylsalicylic acid (ASA) ,chlorpropamide and acizol transdermal therapeutic systems (TTS),made of biocompatible materials,were studied.It was shown that the matrix TTS application provided constant drug concentra tion in blood for prolonged time period (up to 27 h). The elimination half-life and mean residence time during TTS application are higher in comparison with traditional drug forms. ASA and chlorpropamide peak plasma concentrations were lower in comparison with traditional routes of drug administration. ASA and acizol bioavailability increased in 8.7 and 22.3 times respectively in case of transdermal adminis tration as compared to the traditional routes of drug administration.

作者: Basok Yu.B. Alekseeva 0.S. Salomatina L.A. Zaitseva M.A. Sevastianov V.I.

作者单位: Shumakov National Scientific Center of Transplantology and Artificial Organs 123182,Moscow,Shchukins Shumakov National Scientific Center of Transplantology and Artificial Organs 123182,Moscow,Shchukins Institute of Biomedical Research and Technology,119146,Moscow,P.0.B.446,ANO IBRT

会议类型: 国际会议

会议名称: The 10th China-Russia System on Advanced Materials and Technologies(第十届中俄新材料新工艺研讨会)

会议地点: 浙江嘉兴

会议语种:英文

页码: 521-524

在线出版日期: 2009-10-20（万方平台首次上网日期，不代表论文的发表时间）