Improved Selenium Status by Consumption of Wheat Biofortifled with Selenium Does Not Modify DNA Damage in Lymphocytes of Healthy Older Australian Men
(0) Moderate selenium (Se) deficiency is associated with various pathological conditions in humans (Rayman 2000).Recent studies suggest that increased intake of organic Se may reduce risk of cancers;however a supra-nutritional dose is required for the beneficial effect to occur (Duffield-Lillico et al.,2002;Duffield-Lillico et al.,2003).Genome instability,resulting from accumulation of DNA damage,is the fundamental cause of certain degenerative diseases,such as cancer (Fenech 2007). Therefore,increased DNA damage or genome instability can be used as a sensitive early biomarker to identify those individuals with increased cancer risk.In western countries,wheat is a major dietary source of Se. The Se content in wheat,predominantly as selenomethionine (Se-Met),can be increased by agronomic biofortification,which involves fertilizing the food crop with the element via soil/leaves (Lyons et al.,2004).However,the effect of increased consumption of Se from Sebiofortified wheat on DNA damage has not been investigated so far. The focus of this study was to test the bioavailability and bioefficacy of Se from biofortified wheat (BIOFORT) and wheat processfortified with Se-met (PROFORT) in humans. The hypothesis of this study was that improved Se status by increased intake of BIOFORT or PROFORT wheat has a beneficial impact on biomarkers of DNA damage and anti-oxidative capacity.
J.Wu G Lyons R.Graham M.Fenech
CSIRO Human Nutrition,Gate 13,Kintore Avenue,Adelaide,SA5000,Australia
国际会议
The First International Conference on Selenium in the Environment and Human Health(第一届硒与环境和人体健康国际会议)
苏州
英文
29-30
2009-10-01（万方平台首次上网日期，不代表论文的发表时间）