The Role of Selenium in Fetal Development and Animal Health
Selenium (Se) was first determined to be an essential trace element by Schwarz and Foltz (1957) when it was reported that Se prevented liver necrosis in rats.Subsequently,Muth et al.(1958) prevented nutritional muscular dystrophy (NMD) in lambs by supplementation of Se.Rotruck et al.(1973) reported that glutathione peroxidase contains Se,thereby establishing a specific biological function for se.Signs of a nutritional Se deficiency include NMD,reduced litter size and lambing rate,liver necrosis,lowered ratios of T3 to T4,reduced serum immunoglobulins,and increased incidences of retained fetal membranes and mastitis. Assessment of nutritional Se status in animals is generally performed by measuring blood glutathione peroxidase (GPX1) activity or Se concentration. Although skeletal muscle contains most of the Se in the body,mammalian liver is considered the main storage tissue because it contains the greatest concentration of Se compared to other organs.
R.L.Kincaid
Animal Sciences Department,Washington State University,Pullman,WA 99164,USA
国际会议
The First International Conference on Selenium in the Environment and Human Health(第一届硒与环境和人体健康国际会议)
苏州
英文
55-56
2009-10-01（万方平台首次上网日期，不代表论文的发表时间）